The blaze destroyed 50 structures as it spread, and forced the evacuation of an estimated 1,000 people, officials said.
The cause of the fire, which has been burning for one day, remains under investigation and evacuation orders for Weed, Lake Shastina and Edgewood, are in place.
“This incident is rapidly changing and our staff and partners are doing everything they can to get everyone to safety,” the Siskiyou County Sheriff’s Office said.
Officials in Siskiyou County are also battling the Mountain Fire, which had grown to cover 4,812 acres with 5 percent containment.
The fire was burning in steep terrain and spotting farther as it spread, prompting the evacuation of over 300 people, according to Cal Fire.
“Fire continues to burn in timber. Fire was extremely active throughout the night. Fire is pushing towards the north,” the Cal Fire Siskiyou Unit said.
The cause of the Mountain Fire remains under investigation and evacuations have been ordered.
Meanwhile in Southern California, the Route Fire in Los Angeles County was at 5,208 acres Saturday evening with 87% containment, according to an update from the Los Angeles County Fire Department.
Two structures were destroyed and hundreds more were threatened, according to the Fire Department.
Firefighting operations continued overnight with a focus on mopping up hot spots and further building containment lines, the update said.
“Today ground resources will focus on mopping up hot spots and furthering containment. Excessive heat, low humidity and steep terrain continue to pose the biggest challenge for firefighters,” the fire department said.