Thu. Dec 1st, 2022

Today President Joe Biden signed National Security Memorandum-15 (NSM-15) and launched the National Biodefense Strategy and Implementation Plan for Countering Biological Threats, Enhancing Pandemic Preparedness, and Achieving Global Health Security (the Strategy).

As the President has said, there are no walls high enough or oceans wide enough to keep out biothreats and protect our communities. The Strategy reflects the Biden-Harris Administration’s comprehensive plan to protect our nation from future pandemics and biological threats.  It outlines a set of bold goals to transform the nation’s biodefenses and health security by launching a whole-of-government effort across 20 Federal Agencies to detect, prevent, prepare for, respond to, and recover from biological incidents, in partnership with our international, state, local, tribal, territorial, and private sector partners. NSM-15 supports execution of the strategy by strengthening the coordination of biodefense efforts across government.

Infectious diseases that cross borders and disrupt societies are a threat to our national security and global stability.  COVID-19 is the latest example of how biological threats can devastate communities across America and around the world, resulting in millions of deaths and trillions of dollars of economic losses globally. In addition to COVID-19, the global community is concurrently fighting outbreaks of monkeypox, polio, Ebola, highly pathogenic avian influenza, and other diseases, stretching thin global resources and demonstrating gaps in our current preparedness.  And, the risks of weaponization of biological agents are expanding. 

The United States must be prepared for outbreaks from any source – whether naturally occurring, accidental, or deliberate in origin. Urbanization, climate change, and habitat encroachment increase the risk of an outbreak emerging from animal reservoirs. Global interconnectedness accelerates the speed at which infectious diseases spread across the world, especially when coupled with overwhelmed health systems. Furthermore, the norm against the development and use of biological weapons has been challenged by state and non-state actors over the past several decades.

The Administration is already implementing key actions in the Strategy with existing funding. However, fully achieving these transformative objectives will require the support of Congress to provide additional resources, including the President’s $88 billion request over five years for pandemic preparedness and biodefense. The Administration looks forward to working with Congress to implement this investment strategy to save trillions of dollars and millions of lives. 

The Strategy sets out to: 
Detect pandemics and other biological threats:  The Strategy aims to transform early warning of infectious disease threats by accelerating the development and deployment of new technologies that can rapidly detect novel pathogens. It will improve real-time information for decision-making by planning for an enduring all-hazards hospital data collection system, expanding platforms to integrate and share data for response, and improving data sharing internationally. These efforts build on the recently launched Center for Forecasting and Outbreak Analytics, which creates the equivalent of a “national weather service” for infectious disease outbreaks, enabling rapid, effective decision-making to improve outbreak response using data, modeling, and analytics.

Prevent outbreaks from becoming epidemics and prevent biological incidents before they happen by:

  • Stopping outbreaks at their source through strengthening global health security:  The United States will support at least 50 countries to better prevent, detect, and respond to infectious disease threats, while encouraging other donors and partners to support an additional 50 countries.  The United States will also invest in critical multilateral institutions that further strengthen the global health architecture.  The Administration has already accelerated this effort by leading the charge to establish a groundbreaking new Financial Intermediary Fund for Pandemic Prevention, Preparedness, and Response at the World Bank. With the United States and more than 20 countries contributing over $1.4 billion in seed funding at its outset, this new fund will help fill major preparedness gaps at the national, regional, and global level. The Strategy also builds on USAID’s announcement earlier this year committing $150 million to the Coalition for Epidemic Preparedness Innovations to accelerate the development of life-saving vaccines and countermeasures against biological threats. The United States will continue to support and strengthen the World Health Organization, which plays an essential role in strengthening health systems around the world to better prepare for and respond to health emergencies.
  • Strengthening laboratory biosafety and biosecurity: The United States will work with domestic and international partners to prevent laboratory accidents by strengthening biosafety laboratory capacity, reinforcing norms of responsible conduct for biological research, and accelerating biosafety and biosecurity innovation in the United States and abroad. These efforts include galvanizing support for multilateral biosafety and biosecurity commitments, and establishing international mechanisms to enhance biosafety and biosecurity globally.
  • Deterring use and development of bioweapons: The United States will also invest in pathbreaking technologies to detect and attribute biological weapons use, and work with foreign partners to prevent use and respond decisively if biological weapons are deployed. The United States will work to strengthen international norms against traditional and novel biological weapons, including through efforts under the Biological Weapons Convention to foster greater transparency among all nation-states.

Prepare for pandemics and other biological incidents: The Strategy aims to transform our preparedness to respond to outbreaks, building on the American Pandemic Preparedness Plan: Transforming Our Capabilities, released by the Administration in 2021. The United States will work to strengthen and modernize domestic public, veterinary, and plant health capacity at every level, from rural jurisdictions to large cities, so that outbreaks in humans, animals, and plants can be identified and controlled quickly and equitably. This effort includes recruiting, training, and sustaining a robust, flexible, permanent cadre of essential critical health infrastructure workers, outbreak emergency responders, public health laboratory scientists, technicians, data quality managers, and animal disease epidemiologists in our territories and all 50 states. This Strategy will also enhance the coordination of evidence-based public health information campaigns across Federal, state and local governments, with the goal of reaching 80% of the American population.

The Strategy also aims to realize new ambitious timelines in the development of novel countermeasures following the determination of a nationally or internationally significant biological incident (including a high consequence outbreak or potential pandemic). These targets reinforce key elements of the 100 Days Mission, which was welcomed by President Biden and G7 leaders last year and is catalyzing international cooperation in support of urgent global biodefense goals. Over the next 5-10 years, it aims to:

  • Enable testing within 12 hours, surge tens of thousands of diagnostic tests within one week, and develop rapid diagnostics within 90 days;
  • Develop vaccines within 100 days; manufacture enough vaccine for the population of the United States within 130 days; and work with international partners to develop sufficient vaccine supply for high-risk global populations within 200 days; and,
  • Accelerate therapeutic development and validation to repurpose existing drugs within 90 days or develop novel therapeutics within 180 days.

Rapidly respond to outbreaks when they occur: To leverage these capabilities effectively, the Strategy strengthens the United States’ readiness to launch a coordinated, comprehensive, equitable response to any significant biological incident within days.  This effort includes preparing to activate an integrated Federal research agenda within 14 days of the determination of a domestically or internationally significant biological incident, and a clinical trials infrastructure within 14 days of identifying a viable countermeasure to rapidly evaluate vaccines, therapeutics, and diagnostics during a response.

Recover from a pandemic or biological incident: Finally, the Strategy ensures that the Federal government will be prepared to coordinate a long-term, equitable recovery strategy for any significant biological incident, in close partnership with state, local, tribal, and territorial governments and communities.

To support execution of the Strategy, the promulgation of the National Security Memorandum-15 (NSM-15) on Countering Biological Threats, Enhancing Pandemic Preparedness, and Achieving Global Health Security strengthens the coordination of biodefense efforts across the Federal government by:

  • Centralizing oversight of policy coordination at the White House to ensure accountability for implementing the Strategy and in so doing to bring together the strengths of all Federal agencies.
  • Directing departments and agencies to prioritize biodefense and implementation of the Strategy in their annual budgets.
  • Directing the Intelligence Community to closely monitor the evolving biothreat threat landscape and provide critical and potentially time-sensitive information needed to address naturally occurring, accidental, and deliberate biothreats.
  • Ensuring the Federal government continuously adapts to the evolving threat landscape by exercising annual biodefense emergency response plans, reviewing ongoing responses, and adjusting Federal priorities on a regular basis to account for lessons learned.

Collectively, these efforts will help protect the American people against disease outbreaks, pandemics, and biological weapons use, and they will enable us to equitably strengthen the health of our homeland.

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