Sun. Dec 4th, 2022

Levi’s Stadium will be the center of the NFL world on Monday Night Football. The San Francisco 49ers will welcome the Los Angeles Rams to town for a Week 4 showdown between division-rivals. The NFC West foes will engage in a rematch of last season’s NFC Championship Game, which the Rams won on their way to the Super Bowl. Los Angeles is 2-1 overall and 1-0 on the road this season, with San Francisco entering at 1-2 overall and 1-0 at home.

Kick-off is at 8:15 p.m. ET in San Francisco. Caesars Sportsbook lists the 49ers as two-point home favorites, while the over/under, or total number of points Vegas thinks will be scored, is 42.5 in the latest 49ers vs. Rams odds. Before making any Rams vs. 49ers picks and NFL predictions, you need to see what SportsLine expert Tom Fornelli has to say.

The CBS national writer went a profitable 29-16-1 in his last 46 NFL picks. What’s more, he has demonstrated a particularly sharp eye for the 49ers. In fact, Fornelli has gone a stunning 17-6 on picks involving San Francisco. Anyone who has followed him is way up.

Now, Fornelli has set his sights on Rams vs. 49ers and just locked in his picks and MNF predictions. You can head to SportsLine to see his picks. Now, here are several NFL odds and betting lines for Rams vs. 49ers:

  • 49ers vs. Rams spread: 49ers -1.5 
  • 49ers vs. Rams over/under: 42.5 points 
  • 49ers vs. Rams money line: 49ers -130, Rams +110 
  • LAR: Rams are 11-13 against the spread in their last 24 games 
  • SF: 49ers are 13-10 against the spread in their last 23 games 
  • 49ers vs. Rams picks: See picks here

Featured Game | San Francisco 49ers vs. Los Angeles Rams

Why the Rams can cover

Los Angeles has a potentially friendly defensive matchup against San Francisco. The 49ers enter Week 4 as the No. 28 team in scoring offense and are No. 24 in total yardage. San Francisco is No. 29 in passing offense and have generated only two passing touchdowns in three games. The Rams are forcing giveaways on 24.1% of defensive possessions this season, a top-five mark, and are uniquely set up to slow San Francisco’s attack.

The 49ers rely heavily on the running game, and the Rams are in the top 10 in rushing defense, giving up only 281 yards on the ground in three games. Los Angeles is yielding only 3.8 yards per carry and is adept in the red zone, allowing a touchdown on only half of the trips inside the 20-yard line in 2022.

Why the 49ers can cover

Keyed by Nick Bosa, the 49ers came flying out of the gate in 2022 with elite defensive play. San Francisco leads the NFL in first downs allowed (43), passing yards allowed (148.3 per game), passing touchdowns allowed (two), and yards per drive allowed (20.0), with other top-flight metrics across the board. The 49ers are giving up only 12.3 points per game, No. 3, which includes 0.91 points allowed per drive and a scoring percentage allowed of 14.7%. San Francisco is also No. 2 in total defense, yielding 227 total yards per game, and no team has better marks in yards per play allowed (3.9) and opponent punt rate (61%) than the 49ers. 

The 49ers are also excellent against the run, giving up 2.8 yards per carry and 78.7 yards per game, and Bosa is setting the pace of the league with 11 quarterback hits in three weeks. Bosa, a two-time Pro Bowl pass rusher, is also in the top three in sacks (four) and pressures (14) with league-leading marks in both quarterback hits (43) and tackles for loss (25) since the start of the 2021 season.

How to make 49ers vs. Rams picks

Fornelli has analyzed this matchup and while we can tell you he’s leaning Under on the point total, he has also discovered a critical X-factor that has him jumping all over one side of the spread. He’s only sharing what it is, and which side to back, at SportsLine.

Who wins Rams vs. 49ers on Monday Night Football? And which critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the Rams vs. 49ers spread to back, all from the expert who is an incredible 17-6 on picks involving San Francisco, and find out.





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